Scientists have discovered evidence that environmental influences experienced by a fathercan be passed down to the next generation, "reprogramming" how genes function in offspring.
The new study, conducted by researchers at the University of Massachusetts Medical School and the University of Texas at Austin, shows that environmental cues—in this case, diet—influence genes in mammals from one generation to the next, evidence that until now has been sparse.
These insights, coupled with previous human epidemiological studies, suggest that paternal environmental effects may play a more important role in complex diseases such as diabetes and heart disease than previously believed.
"Knowing what your parents were doing before you were conceived is turning out to be important in determining what disease risk factors you may be carrying," said Oliver J. Rando, principal investigator for the study.
These insights, coupled with previous human epidemiological studies, suggest that paternal environmental effects may play a more important role in complex diseases such as diabetes and heart disease than previously believed.
"Knowing what your parents were doing before you were conceived is turning out to be important in determining what disease risk factors you may be carrying," said Oliver J. Rando, principal investigator for the study.
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